Functional Role of G9a Histone Methyltransferase in Cancer

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Functional Role of G9a Histone Methyltransferase in Cancer

Post-translational modifications of DNA and histones are epigenetic mechanisms, which affect the chromatin structure, ultimately leading to gene expression changes. A number of different epigenetic enzymes are actively involved in the addition or the removal of various covalent modifications, which include acetylation, methylation, phosphorylation, ubiquitination, and sumoylation. Deregulation ...

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2015

ISSN: 1664-3224

DOI: 10.3389/fimmu.2015.00487